Title:
Methyl-directed Mismatch Repair
Source:
http://highered.mheducation.com/sites/9834092339/student_view0/chapter14/methyl-directed_mismatch_repair.html
Date Added:
6/10/2022, 8:36:28 AM
Date Modified:
4/26/2023, 9:28:17 PM
Original Description:
How many errors in DNA replication are too many? DNA polymerase makes an error in DNA synthesis approximately once in every thousand bases added to a DNA strand. An error rate of one in a thousand may sound very low. If a student only got one question in a thousand wrong in a course we would consider him or her an excellent student. In DNA replication every single error can have a potentially disastrous effect on the function of the gene being copied. Each gene is composed of hundreds or thousands of bases and organisms have ten of thousands of genes. An error rate of one in a thousand is going to result in a completely nonfunctional cell in a handful of generations. After DNA replication other factors check for errors and correct them. These factors have similar error rates to DNA polymerase meaning that errors in DNA replication only occur about once in a million times.
ID:
5df00257-fbcd-48e7-8810-5cd89aafe9b3